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Discovery of (1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-ylmethanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profileHUGHES, Robert O; ROGIER, D. J; KE ZHANG et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 9, pp 2626-2630, issn 0960-894X, 5 p.Article

Design and synthesis of novel CCR2 antagonists: Investigation of non-aryl/heteroaryl binding motifsTRUJILLO, John I; WEI HUANG; NEWTON, Robert C et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 6, pp 1827-1831, issn 0960-894X, 5 p.Article

1-2-(2,2,2-Trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitorsTOLLEFSON, Michael B; ACKER, Brad A; JACOBSEN, E. J et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 10, pp 3125-3128, issn 0960-894X, 4 p.Article

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitorsOWEN, Dafydd R; WALKER, John K; MOLYNEAUX, John M et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 15, pp 4088-4091, issn 0960-894X, 4 p.Article

Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonistCHANGSHENG ZHENG; GANFENG CAO; MEI LI et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 5, pp 1442-1446, issn 0960-894X, 5 p.Article

Investigation of the pyrazinones as PDE5 inhibitors: Evaluation of regioisomeric projections into the solvent regionHUGHES, Robert O; MADDUX, Todd; HAN, Seungil et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 21, pp 6348-6352, issn 0960-894X, 5 p.Article

1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitorsTOLLEFSON, Michael B; ACKER, Brad A; JACOBSEN, E. J et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 10, pp 3120-3124, issn 0960-894X, 5 p.Article

Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidaseNICHOLAS, Gillian M; ECKMAN, Lisa L; RAY, Satyajit et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 17, pp 2487-2490, issn 0960-894XArticle

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